HORDB

ID: hor002033
Uniprot ID: Q95335
Protein name: GnRH-associated peptide 1
Gene name: GNRH1
Organism: Tupaia belangeri (Common tree shrew) (Tupaia glis belangeri)
Family: GnRH family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Tupaia (genus), Tupaiidae (family), Scandentia (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity; GO:0005183 gonadotropin hormone-releasing hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0005615 extracellular space

Sequence: NAENLIDSFQEIAKEADQLAEPQHFECTISQPRSPLRALKGALESLIEEETGQKKI
Length: 56(37-92)
Propeptide: MELVPKFLAGLILLTLCVGGCYAQHWSYGLRPGGKRNAENLIDSFQEIAKEADQLAEPQHFECTISQPRSPLRALKGALESLIEEETGQKKI
Signal peptide: MELVPKFLAGLILLTLCVGGCYA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002033_AF2.pdb

hor002033_ESM.pdb

Mass:	724723	Formula:	C272H441N75O92S
Absent amino acids:	MVWY	Common amino acids:	E
pI:	4.33	Basic residues:	7
Polar residues:	11	Hydrophobic residues:	19
Hydrophobicity:	-65.71	Boman Index:	-12105
Half-Life:	1.4 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	87.32
Instability Index:	7733.04	Extinction Coefficient cystines:	0
Absorbance 280nm:	0